I had faced with that issue on my work and with Microsoft support we found the core issue and solved it.
Unfortunately, I haven't been able to reproduce this issue in my home lab, but I'll try to describe all main points.
Procmon was showing that "MSExchangeMailboxReplication.exe" process always (hundreds of times per second) try to open (RegOpenKey) "HKLM\SOFTWARE\Microsoft\ExchangeServer\v15\ActiveManager\TestOverride" reg key.
Adding the "TestOverride" registry key doesn't solve the problem. The process started to searching other keys.